Specification No. V 07

Regrapex-R® forte

whole grape extract enriched with 35 % resveratrol

BULK

Description: A whole extract from red grapes of Vitis vinifera, grown in southern France. The fine powder contains 98% trans-resveratrol derived from dried roots of Polygonum cuspidatum. The product contains concentrated active principles found in whole red grapes (simple polyphenolic acids, flavonoids, anthocyanins and oligomeric proanthocyanidines - OPC´s). The product is standardized to min. 35 % (w/w) trans-resveratrol and max. 0.3 % (w/w) emodin complex.

Macroscopic characters:
Color: brown
Odor: odorless
Taste: characteristic bitter-astringent
Solubility: slightly soluble in water, soluble in alcohols and ethylacetate
Composition:  
1 g of the bulk consists of:  
trans-Resveratrol 98% from Polygonum cuspidatum
 min. 380 mg
Whole red grape extract from Vitis vinifera
 ad 1000 mg
Tests: Limits: Methods:
Appearance: violett-brown powder  
Loss on drying (105 °C): max. 10.0 % Ph. Eur. 5th Ed. <2.2.32>
Heavy metals: max. 0.002 % Ph. Eur. 5th Ed. <2.4.8>
Ethanol (GC): max. 5000 ppm NQ V07, test No.3
Ethylacetate (GC): max. 500 ppm NQ V07, test No.4
trans-Resveratrol, HPLC external standard calculated on dry matter: min. 350 mg/g NQ V07, test No.4
Emodin complex (emodin and emodin glycosides) (HPLC, external standard as emodin, calculated on dry matter): max. 3.0 mg/g NQ V07, test No.5
Total polyphenols (Folin-Ciocalteu as gallic acid) min. 500 mg/g NQ V07, test No.6
Microbiological test:
Total aerobic microbial count: <10 000 cfu/g Ph.Eur 5th Ed. <2.6.12>
Combined yeast and molds count: <100 cfu/g Ph.Eur 5th Ed. <2.6.12>
Escherichia coli in 1 g absent Ph.Eur 5th Ed. <2.6.13>
Salmonella in 10 g: absent Ph.Eur 5th Ed. <2.6.13>
Staphylococcus aureus in 1 g: absent Ph.Eur 5th Ed. <2.6.13>
Storage conditions: Keep in dark, up to 25°C
Shelf life: 3 years

*NQ = Norm of Quality